Jeffery Tessem

Research Interests

Both Type 1 and Type 2 diabetes are caused by a relative insufficiency in functional β-cell mass. Current therapeutic options for diabetes include daily insulin injections to maintain normoglycemia, pharmacological agents to stimulate β-cell function and enhance insulin sensitivity, or islet transplantation. A major obstacle to greater application of islet transplantation therapy is the scarcity of human islets. Thus, new methods for expansion of β-cell mass, applied in vitro to generate the large numbers of human islet cells needed for transplantation, or in situ to induce expansion of the patients remaining β-cells, could have broad therapeutic implications for this disease. To this end, our lab is interested in delineating the molecular pathways that increase β-cell proliferation, enhance glucose stimulated insulin secretion, and protect against β-cell death.

Teaching Interests

My teaching interests focus on molecular biology, microbiology, metabolism, biochemistry and cellular function. I am interested in metabolic disorders that cause human diseases.

Education

• Postdoctoral Fellowship, Beta Cell Biology , Duke University (2013)
• Ph.D., Biochemistry and Molecular Biology , Biophysics and Genetics, University of Colorado Health Sciences Center (2007)
• BS, Microbiology , Chemistry and Portugues, Brigham Young University (2001)

Licenses and Certifications

• The Jackson Laboratory, Surgical Techniques in the Laboratory Mouse (2021 - Present)

Honors and Awards

• Outstanding Research Award, BYU Life Sciences College (2022 - 2023)
• Skaggs Distinguished Mentoring Fellowship, BYU Life Science College (2020 - 2023)
• 2018 Meg Award, BYU ORCA (2018 - 2019)
• Innovative Basic Science Award, American Diabetes Association (2017 - 2019)
• Research Award, Diabetes Action Research and Education Foundation (2017 - 2018)
• 2016 MEG Recipient, BYU ORCA (2016 - 2018)
• JDRF Utah Chapter Hope for the Future Award, Utah Chapter of the Juvenile Diabetes Research Foundation (2016 - 2017)
• Beta Cell Biology Consortium Investigator Scholarship, Beta Cell Biology Consortium (2011 - 2011)
• Keystone Symposium/NIDDK Scholarship, Keystone Symposium (2010 - 2010)

Memberships

• American Association for the Advancement of Science (2017 - Present)
• American Society for Biochemistry and Molecular Biology (2017 - Present)
• American Physiological Society (2014 - Present)
• Danish Diabetes Academy (2014 - Present)
• American Diabetes Association (2011 - Present)

Professional Citizenship

• Grant Proposal Reviewer, External, National Institute of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Diabetes, Endocrinology, and Metabolic Diseases B (DDK-B) Study Section (2024 - Present)
• Editorial Review Board Member, Frontiers in Endocrinology, Diabetes: Study of Pancreatic Islets Based on Human Models to Understand Pathogenesis of Diabetes (2021 - Present)
• Editorial Review Board Member, Nutrition Research (2021 - Present)
• Editorial Review Board Member, Biology Journal (2020 - Present)
• Editorial Review Board Member, Pharmaceutical Journal (2020 - Present)
• Editorial Review Board Member, Frontiers in Endocrinology, Diabetes: Molecular Mechanisms (2019 - Present)
• Reviewer, Ad Hoc Reviewer, Diabetes Journal (2016 - Present)
• Reviewer, Ad Hoc Reviewer, Journal of Molecular Cell Biology (2016 - Present)
• Reviewer, Ad Hoc Reviewer, PLOS ONE Journal (2016 - Present)
• Reviewer, Ad Hoc Reviewer, American Journal of Physiology - Endocrinology and Metabolism (2016 - Present)
• Committee/Council Member, JDRF (2015 - Present)
• Reviewer, Ad Hoc Reviewer, JDRF (2013 - Present)
• Committee/Council Member, American Physiology Society-Endocrinology and Metabolism Section (2023 - 2026)
• Committee/Council Member, American Diabetes Association National Islet Biology, Development, and Function interest group (2022 - 2024)
• Committee/Council Member, American Physiology Society-Endocrinology and Metabolism Section (2020 - 2023)
• Committee/Council Member, American Diabetes Association National Islet Biology, Development, and Function interest group (2021 - 2022)
• Committee/Council Member, American Physiology Society-Communication Committee (2017 - 2020)
• Reviewer, Ad Hoc Reviewer, NIN-NIDDK-Molecular and Cellular Endocrinology Review Panel (2016 - 2019)

Courses Taught

Show Previous Years

Publications

Jeffery S Tessem Jacob Herring Adam Wynn Talon Aitken Nathan Walker Kate Whalen Michael G. Sweet Lisard Iglesias-Carres Peter N. Ellsworth Jared D. Carter Dahlia M. Nielsen David L. Aylor Jeffery S Tessem Andrew P. Neilson Kathryn C. Racine Lisard Iglesias-Carres Jacob A. Herring Kristopher L. Wieland Peter N. Ellsworth Jeffery S Tessem Mario G. Ferruzzi Colin D. Kay Andrew P. Neilson Jacob A. Herring Jacqueline E. Crabtree Jonathon T Hill Jeffery S Tessem Nelmari Ruiz-Otero Jeffery S Tessem Ronadip R. Banerjee Peter N. Ellsworth Jacob A. Herring Aaron H. Leifer Jason D. Ray Weston S. Elison Peter Daniel Poulson Jacqueline E. Crabtree Pam Marie Van Ry Jeffery S Tessem Emily S. Krueger Laura E. Griffin Joseph L. Beales Trevor S. Lloyd Nathan J. Brown Weston S. Elison Colin D. Kay Andrew P. Neilson Jeffery S Tessem Jeffery S Tessem Yumi Imai Scott Soleimanpour Jeffery S Tessem Kathryne Racine Lisard Iglesias-Carres Jacob Herring Mario Ferruzzi Colin Kay Andrew Nelson Jeffery S Tessem Lisard Iglesias-Carres Emily Krueger Jacob Herring Andrew Nelson Laura E. Griffin Lauren Essenmacher Kathryn C. Racine Lisard Iglesias-Carres Jeffery S Tessem Susan M. Smith Andrew P. Neilson Emily S. Krueger Trevor S. Lloyd Jeffery S. Tessem E S Krueger J L Beales K B Russon W S Elison J R Davis Jason Merrell Hansen A P Neilson Jason Merrell Hansen Jeffery S Tessem Kathryn Racine Lisard Iglesias-Carres Lauren Essenmacher Gabriella Agnello Jeffery Tessem Mario Ferruzzi Colin Kay Andrew Neilson Daelin M. Jensen Kyle V. Hendricks Austin T. Mason Jeffery S Tessem Jeffery S Tessem Benjamin F. Bitner Jason D. Ray Kyle B. Kener Jacob A Herring Josie A Tueller Deborah K Johnson Claudia M Tellez Freitas Dane W Fauscnact Mitchel E Allen Alexander H Thomson K Scott Weber Ryan P McMillan Matthew W Hulliver David A Brown Andrew P Neilson C Draney M C Austin A H Leifer C J Smith K B Kener T J Aitken K H Hess Albert Edwyn Haines L A Lett A Hernandez-Carretero P T Fueger M Arlotto Jeffery S Tessem B A Parker C M Walton S T Carr Jason Alan Andrus Cheung ECK M J Duplisea E K Wilson C Draney D R Lathen K B Kenner David Morley Thomson Jeffery S Tessem Benjamin Thomas Bikman B A Parker C M Walton S T Carr J L Andrus Cheung ECK M J Duplisea E K Wilson C Draney D R Lathen K B Kenner David Morley Thomson Jeffery S Tessem Benjamin Thomas Bikman K. B. Kener D. J. Munk Chad R Hancock Jeffery S Tessem T J Rowley, 4th B F Bitner J D Ray D R Lathen A T Smithson B W Dallon C J Plowman Benjamin Thomas Bikman Jason Merrell Hansen M R Dorenkott K M Goodrich L Ye S F O'Keefe A P Neilson Jeffery S Tessem C J Banks N W Rodriguez K R Gashler R R Pandya J B Mortenson M D Whited E J Soderblom J W Thompson M A Moseley A R Reddi Jeffery S Tessem M P Torres Benjamin Thomas Bikman Joshua Andersen MaryJane Sampson Daniel R Lathen Blake W Dallon Carrie Draney Jason D Ray Kyle B Kener Brian A Parker Jonathan L Gibbs Jarom S Gropp Jeffery S Tessem Benjamin Thomas Bikman M S Reynolds Chad R Hancock J D Ray K B Kener C Draney K Garland J Hardman Benjamin Thomas Bikman Jeffery S Tessem J D Ray K B Kener B F Bitner B J Wright Michael Barclay Ballard E J Barrett Jonathon T Hill L G Moss Jeffery S Tessem Jeffery S Tessem Karen M Strat Thomas J Rowley Andrew T Smithson Matthew W Hulver Dongmin Liu Brenda M Davey Kevin P Davy Andrew P Neilson Jeffery S Tessem CArrie Draney Amanda E Hobson Samuel G Grover Benjamin O Jack Amanda Hobson Carrie Draney Andrew Stratford Tom C Becker Danhong Lu Michelle Arlotto Jeffery S Tessem Jeffery S Tessem L G Moss L C Chao M Arlotto D Lu M V Jensen S B Stephens P Tontonoz H E Hohmeier C B Newgard Jeffery S Tessem Jan N Jensen Hanna Pelli Xu M Dai Xiao H Zong Richard E Stanley Jan Jensen James DeGregori Jeffery S Tessem Jonathon C Schisler Patrick T Fueger Daniella A Babu Hans E Hohmeier Danhong Lu Thomas C Becker Bashoo Naziruddin Marlon Levy Ragvhavendra G Mirmira Christopher B Newgard Jeffery S Tessem J DeGregori F X Li J W Zhu Jeffery S Tessem J Beilke M Varella-Garcia J Jensen C J Hogan J DeGregori