Publications
Sweet MG, Iglesias-Carres L, Ellsworth PN, Carter JD, Nielsen DM, Aylor DL, Tessem JS, Neilson AP. Phenotype variability in diet-induced obesity and response to (-)-epigallocatechin gallate supplementation in a Diversity Outbred mouse cohort: A model for exploring gene x diet interactions for dietary bioactives. Nutr Res. 2024 Nov 26;133:78-93. doi: 10.1016/j.nutres.2024.11.008. Epub ahead of print. PMID: 39705912.
Racine KC, Iglesias-Carres L, Herring JA, Wieland KL, Ellsworth PN, Tessem JS, Ferruzzi MG, Kay CD, Neilson AP. The high-fat diet and low-dose streptozotocin type-2 diabetes model induces hyperinsulinemia and insulin resistance in male but not female C57BL/6J mice. Nutr Res. 2024 Sep 14;131:135-146. doi: 10.1016/j.nutres.2024.09.008. Epub ahead of print. PMID: 39389000.
Herring JA, Crabtree JE, Hill JT, Tessem JS. Loss of glucose-stimulated β-cell Nr4a1 expression impairs insulin secretion and glucose homeostasis. Am J Physiol Cell Physiol. 2024 Oct 1;327(4):C1111-C1124. doi: 10.1152/ajpcell.00315.2024. Epub 2024 Sep 2. PMID: 39219449.
Ruiz-Otero N, Tessem JS, Banerjee RR. Pancreatic islet adaptation in pregnancy and postpartum. Trends Endocrinol Metab. 2024 Sep;35(9):834-847. doi: 10.1016/j.tem.2024.04.007. Epub 2024 May 1. PMID: 38697900.
Ellsworth PN, Herring JA, Leifer AH, Ray JD, Elison WS, Poulson PD, Van Ry PM, Tessem JS. Nkx6.1 mediated proliferation is dependent on the Transcription Factor CEBP/A. Biology 2024, 13, 110. https://doi.org/10.3390/biology13020110
Krueger, E.S.; Griffin, L.E.; Beales, J.L.; Lloyd, T.S.; Brown, N.J.; Elison, W.S.; Kay, C.D.; Neilson, A.P.; Tessem, J.S. Bioavailable Microbial Metabolites of Flavanols Demonstrate Highly Individualized Bioactivity on In Vitro β-Cell Functions Critical for Metabolic Health. Metabolites 2023, 13, 801. https://doi.org/10.3390/metabo13070801
Imai Y, Soleimanpour SA, Tessem JS. Editorial: Study of pancreatic islets based on human models to understand pathogenesis of diabetes. Front Endocrinol (Lausanne). 2023 Jan 9;13:1128653. doi: 10.3389/fendo.2022.1128653. PMID: 36714557; PMCID: PMC9875287.
Racine KC, Iglesias-Carres L, Herring JA, Ferruzzi MG, Kay CD, Tessem JS, Neilson AP. Cocoa extract exerts sex-specific anti-diabetic effects in an aggressive type-2 diabetes model: A pilot study. Biochem Biophys Res Commun. 2022 Oct 20;626:205-210. doi: 10.1016/j.bbrc.2022.08.018. Epub 2022 Aug 11. PMID: 35994831.
Allen, J.G.; Tessem, J.S. Ca2+ Sensors Assemble: Function of the MCU Complex in the Pancreatic Beta Cell. Cells 2022, 11, 1993. https://pubmed.ncbi.nlm.nih.gov/35805078/
Iglesias-Carres L, Krueger ES, Herring JA, Tessem JS, Neilson AP. Potential of Phenolic Compounds and Their Gut Microbiota-Derived Metabolites to Reduce TMA Formation: Application of an In Vitro Fermentation High-Throughput Screening Model. J Agric Food Chem. 2022 Mar 2. doi: 10.1021/acs.jafc.2c00247. Epub ahead of print. PMID: 35235743.
Krueger, E.S.; Beales, J.L.; Russon, K.B.; Elison, W.S.; Davis, J.R.; Hansen, J.M.; Neilson, A.P.; Hansen, J.M.; Tessem, J.S. Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions. Biomolecules 2021, 11, 1892. https://doi.org/10.3390/biom11121892
Aitken TJ, Crabtree JE, Jensen DM, Hess KH, Leininger BR, Tessem JS. Decreased proliferation of aged rat beta cells corresponds with enhanced expression of the cell cycle inhibitor p27KIP1. Biol Cell. 2021 Sep 14. doi: 10.1111/boc.202100035. Epub ahead of print. PMID: 34523154.
Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keles S, Moskowitz IP, Keller MP, Attie AD. Identification of direct transcriptional targets of NFATC2 that promote β-cell proliferation. J Clin Invest. 2021 Sep 7:144833. doi: 10.1172/JCI144833. Epub ahead of print. PMID: 34491912.
Krueger ES, Lloyd TS, Tessem JS. The accumulation and molecular effects of Trimethylamine N-Oxide on Metabolic Tissues: It’s not all bad. Nutrients. 2021 Aug 21;13(8), 2873; https://doi.org/10.3390/nu13082873.
Jensen DM, Hendricks KV, Mason AT, Tessem JS. Good Cop, Bad Cop: The Opposing Effects of Macrophage Activation State on Maintaining or Damaging Functional β-Cell Mass. Metabolites. 2020 Nov 26;10(12):485. doi: 10.3390/metabo10120485. PMID: 33256225; PMCID: PMC7761161.
Griffin LE, Essenmacher L, Racine KC, Iglesias-Carres L, Tessem JS, Smith SM, Neilson AP. Diet-induced obesity in genetically diverse collaborative cross mouse founder strains reveals diverse phenotype response and amelioration by quercetin treatment in 129S1/SvImJ, PWK/EiJ, CAST/PhJ, and WSB/EiJ mice. J Nutr Biochem. 2021 Jan; 87:108521. doi: 10.1016/j.jnutbio.2020.108521. Epub 2020 Oct 8. PMID: 33039581.
Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM. Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;1866(8):165805. doi: 10.1016/j.bbadis.2020.165805. Epub 2020 Apr 24. PMID: 32339642; PMCID: PMC8432303.
Herring JA, Elison WS, Tessem JS. Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues. Cells. 2019 Nov 1;8(11):1373. doi: 10.3390/cells8111373. PMID: 31683815; PMCID: PMC6912296.
Draney C, Austin MC, Leifer AH, Smith CJ, Kener KB, Aitken TJ, Hess KH, Haines AC, Lett E, Hernandez-Carretero A, Fueger PT, Arlotto M, Tessem JS. HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27. Biochem J. 2018 Dec 19;475(24):3997-4010. doi: 10.1042/BCJ20180465. PMID: 30322885.
Bitner BF, Ray JD, Kener KB, Herring JA, Tueller JA, Johnson DK, Tellez Freitas CM, Fausnacht DW, Allen ME, Thomson AH, Weber KS, McMillan RP, Hulver MW, Brown DA, Tessem JS, Neilson AP. Common gut microbial metabolites of dietary flavonoids exert potent anti-diabetes activities in beta cell and skeletal cell models. J Nutr Biochem. 2018 Dec; 62:95-107. doi: 10.1016/j.jnutbio.2018.09.004. Epub 2018 Sep 15.
Parker BA, Smith J, Walton C, Hubbard C, Andrus J, Perry K, Draney C, Lathen DR, Kener KB, Holland WL, Thomson DM, Tessem JS, Bikman BT. Beta-hydroxybutyrate elicits favorable mitochondrial changes in skeletal muscle. Int J Mol Sci. 2018 Aug 1; 19(8). pii: E2247. doi:10.3390/ijms19082247.
Kener KB, Munk DJ, Hancock CR, Tessem JS. High-resolution Respirometry to Measure Mitochondrial Function of Intact Beta Cells in the Presence of Natural Compounds. J Vis Exp. 2018 Jan 23;(131). doi: 10.3791/57053. PubMed PMID:29443067.
Rowley TJ 4th, Bitner BF, Ray JD, Lathen DR, Smithson AT, Dallon BW, Plowman CJ, Bikman BT, Hansen JM, Dorenkott MR, Goodrich KM, Ye L, O'Keefe SF, Neilson AP, Tessem JS. Monomeric cocoa catechins enhance β-cell function by increasing mitochondrial respiration. J Nutr Biochem. 2017 Nov; 49:30-41. doi: 10.1016/j.jnutbio.2017.07.015. Epub 2017 Jul 27. PubMed PMID: 28863367.
Sampson MJ, Lathen DR, Dallon BW, Draney C, Ray JD, Kener KB, Parker BA, Gibbs JL, Gropp JS, Tessem JS, Bikman BT. β-Hydroxybutyrate improves β-cell mitochondrial function and survival. Journal of Insulin Resistance. 2017 August 31. https://doi.org/10.4102/jir.v2i1.25
Banks CJ, Rodriguez NW, Gashler KR, Pandya RR, Mortenson JB, Whited MD, Soderblom EJ, Thompson JW, Moseley MA, Reddi AR, Tessem JS, Torres MP, Bikman BT, Andersen JL. Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. Mol Cell Biol. 2017 Sep 26;37(20). pii: e00354-17. doi: 10.1128/MCB.00354-17. Print 2017 Oct 15. PubMed PMID: 28739857; PubMed Central PMCID: PMC5615182.
Strat KM, Rowley TJ 4th, Smithson AT, Tessem JS, Hulver MW, Liu D, Davy BM, Davy KP, Neilson AP. Mechanisms by which cocoa flavanols improve metabolic syndrome and related disorders. J Nutr Biochem. 2016 Sep; 35:1-21. doi: 10.1016/j.jnutbio.2015.12.008. Epub 2016 Jan 23. Review. PubMed PMID: 27560446.
Reynolds MS, Hancock CR, Ray JD, Kener KB, Draney C, Garland K, Hardman J, Bikman BT, Tessem JS. β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion. Am J Physiol Endocrinol Metab. 2016 Jul 1;311(1): E186-201. doi: 10.1152/ajpendo.00022.2016. Epub 2016 May24. PubMed PMID: 27221116.
Ray JD, Kener KB, Bitner BF, Wright BJ, Ballard MS, Barrett EJ, Hill JT, Moss LG, Tessem JS. Nkx6.1-mediated insulin secretion and β-cell proliferation is dependent on upregulation of c-Fos. FEBS Lett. 2016 Jun;590(12):1791-803. doi:10.1002/1873-3468.12208. Epub 2016 May 26. PubMed PMID: 27164028.
Draney C, Hobson AE, Grover SG, Jack BO, Tessem JS. Cdk5r1 Overexpression Induces Primary β-Cell Proliferation. J Diabetes Res. 2016; 2016:6375804. doi:10.1155/2016/6375804. Epub 2015 Dec 14. PubMed PMID: 26788519; PubMed Central PMCID: PMC4691621.
Hobson A, Draney C, Stratford A, Becker TC, Lu D, Arlotto M, Tessem JS. Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway. Islets. 2015;7(1): e1027854. doi: 10.1080/19382014.2015.1027854. Epub 2015 Jun 1. PubMed PMID: 26030060; PubMed Central PMCID: PMC4588548.
Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB. Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors. Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24. PubMed PMID: 24706823; PubMed Central PMCID: PMC3986138.
Tessem JS, Jensen JN, Pelli H, Dai XM, Zong XH, Stanley ER, Jensen J, DeGregori J. Critical roles for macrophages in islet angiogenesis and maintenance during pancreatic degeneration. Diabetes. 2008 Jun;57(6):1605-17. doi: 10.2337/db07-1577. Epub 2008 Mar 28. PubMed PMID: 18375440; PubMed Central PMCID: PMC2575065.
Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB. Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1. Mol Cell Biol. 2008 May;28(10):3465-76. doi:10.1128/MCB.01791-07. Epub 2008 Mar 17. PubMed PMID: 18347054; PubMed Central PMCID: PMC2423154.
Tessem JS, DeGregori J. Roles for bone-marrow-derived cells in beta-cell maintenance. Trends Mol Med. 2004 Nov;10(11):558-64. Review. PubMed PMID: 15519282.
Li FX, Zhu JW, Tessem JS, Beilke J, Varella-Garcia M, Jensen J, Hogan CJ, DeGregori J. The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12935-40. Epub 2003 Oct 17. PubMed PMID: 14566047; PubMed Central PMCID: PMC240722.